WDR76

Across TCGA patient cohorts, WDR76 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR76-associated genes across cancer lineages are MEK1, eIF4E, and PRDX1. Each is linked with WDR76 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR76-to-partner and partner-to-WDR76 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by WDR76-low versus WDR76-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR76→partner) and Y-score (partner→WDR76) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.515	+3.584	.003	.002	3	2
UCEC	eIF4E →	+0.209	+2.459	.040	.020	3	1
UCEC	PRDX1 →	+0.271	+3.000	.006	.036	3	1
UCEC	XBP1 →	-0.209	-2.986	.002	.035	3	1
UCEC	Bax →	+0.300	+2.179	.009	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+1.000	+3.341	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MEK1 by WDR76 expression — UCEC

Explore this box plot interactively →