WDR76

Across TCGA cell cohorts, WDR76 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR76-associated genes across cancer lineages are MAGEB4, GFRA4, and STRA8. Each is linked with WDR76 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR76-to-partner and partner-to-WDR76 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by WDR76-low versus WDR76-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR76→partner) and Y-score (partner→WDR76) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GFRA4 →	+0.030	+4.930	<.001	.001	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SPRR4 →	+0.093	+4.930	<.001	.001	3	1
LARGE_INTESTINE	LRRC10 →	+0.020	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MAGEB4 by WDR76 expression — LARGE_INTESTINE

Explore this box plot interactively →