WDR59

Across TCGA patient cohorts, WDR59 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR59-associated genes across cancer lineages are PDCD4, Bad_pS112, and Caspase-7-cleavedD198. Each is linked with WDR59 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR59-to-partner and partner-to-WDR59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by WDR59-low versus WDR59-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR59→partner) and Y-score (partner→WDR59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.576	-1.999	<.001	.008	3	3
UCEC	Bad_pS112 →	-0.167	-1.247	.008	.045	3	3
UCEC	Caspase-7-cleavedD198 →	+0.759	+2.522	<.001	<.001	3	3
UCEC	eIF4E →	+0.184	+2.087	.010	.005	3	2
UCEC	JNK2 →	+0.256	+3.611	<.001	.001	3	2
UCEC	MEK1 →	+0.336	+2.087	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PDCD4 by WDR59 expression — UCEC

Explore this box plot interactively →