WDR59

Across TCGA pan-cancer cohorts, WDR59 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated WDR59 data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher WDR59 RNA is associated with better overall survival. In most high-consensus cancer types, elevated WDR59 expression acts as an unfavorable survival marker, although some lineages such as READ and UCS show a favorable association.

READ, UCS, and BLCA are the cancer types where WDR59 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	All	0.848	0.621	.003	38	view →
UCS	OS	Tertile	III,IV	0.520	0.199	.024	30	view →
BLCA	DFS	Tertile	All	0.239	0.588	.004	24	view →
ACC	DFS	Median	All	0.440	0.723	.003	23	view →
COAD	DFS	Quartile	All	0.427	0.615	.013	23	view →
SKCM	DFS	Quartile	III,IV	0.188	0.501	.001	16	view →
LUSC	DFS	Median	III,IV	0.407	0.883	.006	14	view →
SCLC	OS	Median	III,IV	0.778	0.439	.006	11	view →
LAML	DFS	Median	All	0.490	0.297	.039	10	view →
LGG	DFS	Tertile	All	0.766	0.865	.021	8	view →
OV	OS	Tertile	IV	0.562	0.830	.029	6	view →
GBM	DFS	Tertile	All	0.433	0.210	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

WDR59–READ (OS)

Open the READ breakdown →