WDR59

Across TCGA pan-cancer cohorts, WDR59 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of WDR59’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where WDR59 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WDR59 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, HNSC, and THCA are the cancer types where WDR59 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR59 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+0.868	<.001	11	view →
HNSC	All	III,IV	+0.448	<.001	10	view →
THCA	All	II,III,IV	−0.523	<.001	9	view →
KICH	Female	All	−0.773	<.001	7	view →
BRCA	All	III,IV	−0.493	<.001	6	view →
READ	All	All	+0.521	<.001	5	view →
LUAD	All	All	+0.322	<.001	5	view →
CHOL	Male	All	+0.888	<.001	4	view →
STAD	Male	II,III,IV	+0.642	.013	4	view →
LUSC	Male	All	+0.395	<.001	4	view →
KIRC	Male	III,IV	−0.233	.029	1	view →
LIHC	All	All	+0.203	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

WDR59–COAD

Open the COAD breakdown →