WDR59

Across TCGA cell cohorts, WDR59 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,662 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WDR59-associated GO terms across cancer lineages are Nucleic acid catabolic process, RNA catabolic process, and mRNA catabolic process. Each is linked with WDR59 in more than 17 cancer types. Because this analysis shows association rather than direction, both WDR59-to-partner and partner-to-WDR59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleic acid catabolic process grouped by WDR59-low versus WDR59-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR59→partner) and Y-score (partner→WDR59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nucleic acid catabolic process →	+0.066	+1.325	<.001	<.001	3	18
BONE	RNA catabolic process →	+0.083	+0.919	<.001	.004	3	18
BLOOD_Lymphoma	mRNA catabolic process →	+0.060	+0.748	<.001	<.001	3	18
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.091	+0.978	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Late viral transcription →	+0.170	+1.318	<.001	<.001	3	17
BONE	Viral transcription →	+0.135	+1.241	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,662 associations by consensus.

Nucleic acid catabolic process by WDR59 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →