WDR59

Across TCGA cell cohorts, WDR59 mutation is significantly associated with the RNA expression of many other genes, with 313 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR59-associated genes across cancer lineages are TRIM49B, FAM86B2, and OLFM3. Each is linked with WDR59 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR59-to-partner and partner-to-WDR59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM49B grouped by WDR59-low versus WDR59-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR59→partner) and Y-score (partner→WDR59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRIM49B →	+0.070	+2.967	<.001	.003	3	2
LARGE_INTESTINE	FAM86B2 →	+0.774	+3.212	.002	.006	3	2
BLOOD_Leukemia	OLFM3 →	+0.695	+3.889	<.001	<.001	3	1
BLOOD_Leukemia	BHLHE23 →	+0.830	+2.632	.006	.009	3	1
BLOOD_Leukemia	ATP1A4 →	+0.399	+2.857	<.001	.006	3	1
BLOOD_Leukemia	CD8A →	+2.088	+3.283	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 313 associations by consensus.

TRIM49B by WDR59 expression — BLOOD_Leukemia

Explore this box plot interactively →