WDR55

Across TCGA patient cohorts, WDR55 mutation is significantly associated with the RNA expression of many other genes, with 598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR55-associated genes across cancer lineages are RNA5SP204, RNU5E-9P, and MLLT10P2. Each is linked with WDR55 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR55-to-partner and partner-to-WDR55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP204 grouped by WDR55-low versus WDR55-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR55→partner) and Y-score (partner→WDR55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP204 →	+0.414	+2.473	<.001	.003	3	2
UCEC	RNU5E-9P →	+0.231	+3.885	<.001	.008	3	2
UCEC	MLLT10P2 →	+0.187	+2.920	<.001	.003	3	2
HNSC	RNU6-458P →	+0.343	+7.954	<.001	.008	3	1
BLCA	RPL31P1 →	+0.128	+6.147	<.001	.002	3	1
BLCA	RPL12P23 →	+0.142	+5.106	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 598 associations by consensus.

RNA5SP204 by WDR55 expression — UCEC

Explore this box plot interactively →