WDR41

Across TCGA patient cohorts, WDR41 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR41-associated genes across cancer lineages are Notch1, C-Raf, and 14-3-3_beta. Each is linked with WDR41 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR41-to-partner and partner-to-WDR41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by WDR41-low versus WDR41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR41→partner) and Y-score (partner→WDR41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.177	+2.906	.003	.001	3	2
UCEC	C-Raf →	+0.140	+1.700	.021	.044	3	2
UCEC	14-3-3_beta →	-0.094	-3.143	.028	.018	3	1
UCEC	EGFR_pY1068 →	-0.267	-2.222	.012	.011	3	1
UCEC	A-Raf_pS299 →	-0.132	-2.459	.009	.019	3	1
UCEC	GATA6 →	-0.160	-2.108	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Notch1 by WDR41 expression — UCEC

Explore this box plot interactively →