WDR41

Across TCGA pan-cancer cohorts, WDR41 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated WDR41 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WDR41 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated WDR41 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

HNSC, KICH, and LGG are the cancer types where WDR41 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.159	0.517	<.001	95	view →
KICH	OS	Median	All	0.723	1.000	<.001	79	view →
LGG	OS	Median	All	0.729	0.894	<.001	53	view →
MESO	DFS	Tertile	All	0.265	0.472	.003	46	view →
UVM	DFS	Quartile	III,IV	0.234	0.900	.002	42	view →
LIHC	DFS	Tertile	All	0.445	0.661	<.001	40	view →
OV	DFS	Median	All	0.496	0.578	.014	26	view →
SCLC	DFS	Tertile	All	0.202	0.488	.016	24	view →
KIRC	DFS	Quartile	III,IV	0.558	0.221	.004	20	view →
STAD	DFS	Tertile	IV	0.234	0.662	.006	15	view →
KIRP	DFS	Tertile	IV	0.118	0.667	.010	14	view →
ACC	DFS	Tertile	All	0.551	0.808	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

WDR41–HNSC (OS)

Open the HNSC breakdown →