Across TCGA patient cohorts, WDR27 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR27-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and FoxM1. Each is linked with WDR27 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR27-to-partner and partner-to-WDR27 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR27→partner) and Y-score (partner→WDR27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.367	+2.837	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.237	-1.847	.010	.008	3	2
UCEC	FoxM1 →	+0.255	+3.710	.007	<.001	3	2
UCEC	HER3_pY1289 →	+0.062	+2.321	.049	.033	3	2
UCEC	Lck →	+0.191	+1.847	.009	.008	3	2
UCEC	mTOR_pS2448 →	-0.138	-2.202	.011	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Exploration

WDR27 survival (RNA) · tumor vs normal (RNA) · all WDR27 data types