WDFY4

Across TCGA cell cohorts, WDFY4 mutation is significantly associated with the RNA expression of many other genes, with 907 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDFY4-associated genes across cancer lineages are CCDC138, ATG4C, and EIF4E. Each is linked with WDFY4 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDFY4-to-partner and partner-to-WDFY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC138 grouped by WDFY4-low versus WDFY4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDFY4→partner) and Y-score (partner→WDFY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC138 →	+0.927	+3.351	<.001	.003	3	3
LARGE_INTESTINE	ATG4C →	+0.433	+1.483	.001	.002	3	3
LARGE_INTESTINE	EIF4E →	+0.517	+1.299	<.001	.006	3	3
LARGE_INTESTINE	GPBP1L1 →	+0.335	+1.678	.002	.002	3	3
LARGE_INTESTINE	SGCB →	+0.675	+2.000	.006	.009	3	3
LARGE_INTESTINE	RCHY1 →	+0.646	+1.974	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 907 associations by consensus.

CCDC138 by WDFY4 expression — BLOOD_Leukemia

Explore this box plot interactively →