WDFY4

Across TCGA pan-cancer cohorts, WDFY4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated WDFY4 data layer compared with 12 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WDFY4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated WDFY4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where WDFY4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.667	0.535	<.001	135	view →
SKCM	OS	Median	All	0.416	0.271	<.001	108	view →
LUAD	OS	Median	All	0.753	0.623	<.001	91	view →
CESC	DFS	Tertile	All	0.805	0.625	.001	56	view →
KIRC	DFS	Tertile	III,IV	0.834	0.671	.011	50	view →
LGG	DFS	Tertile	All	0.319	0.485	<.001	46	view →
SCLC	DFS	Tertile	All	0.756	0.452	.002	27	view →
SARC	OS	Median	All	0.896	0.777	<.001	26	view →
UCS	DFS	Tertile	IV	0.956	0.250	.024	24	view →
UCEC	OS	Quartile	III,IV	0.747	0.402	.005	24	view →
LAML	DFS	Tertile	All	0.240	0.460	.010	24	view →
PAAD	OS	Tertile	II,III,IV	0.655	0.479	.013	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

WDFY4–HNSC (DFS)

Open the HNSC breakdown →