WBP2NL

Across TCGA patient cohorts, WBP2NL mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WBP2NL-associated genes across cancer lineages are GAPDH, TIGAR, and EGFR_pY1068. Each is linked with WBP2NL in more than 1 cancer types. Because this analysis shows association rather than direction, both WBP2NL-to-partner and partner-to-WBP2NL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by WBP2NL-low versus WBP2NL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WBP2NL→partner) and Y-score (partner→WBP2NL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.782	+3.459	<.001	.005	3	2
UCEC	TIGAR →	+0.141	+1.611	.034	.043	3	2
UCEC	EGFR_pY1068 →	-0.285	-2.115	.009	.019	3	1
UCEC	eIF4E →	+0.188	+2.115	.041	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.172	-2.321	.019	.034	3	1
UCEC	JNK2 →	+0.202	+2.115	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

GAPDH by WBP2NL expression — UCEC

Explore this box plot interactively →