WBP2NL

Across TCGA pan-cancer cohorts, WBP2NL RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of WBP2NL’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WBP2NL RNA is repressed in tumor relative to normal tissue. In most cancer types WBP2NL is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, LIHC, and KIRC are the cancer types where WBP2NL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WBP2NL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.411	<.001	8	view →
LIHC	Male	All	+0.227	<.001	8	view →
KIRC	Male	All	−0.156	<.001	7	view →
HNSC	Male	IV	+0.115	.030	3	view →
CHOL	All	All	+0.671	<.001	2	view →
LUSC	All	III,IV	−0.243	.031	2	view →
UCEC	All	All	−0.213	.025	2	view →
BRCA	Female	All	−0.147	.025	2	view →
LUAD	All	All	+0.158	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

WBP2NL–THCA

Open the THCA breakdown →