WAPL

Across TCGA patient cohorts, WAPL protein abundance is significantly associated with the RNA expression of many other genes, with 9,550 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible WAPL-associated genes across cancer lineages are DNA2, NOLC1, and KIF20B. Each is linked with WAPL in more than 7 cancer types. Because this analysis shows association rather than direction, both WAPL-to-partner and partner-to-WAPL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WAPL versus DNA2 in LSCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WAPL→partner) and Y-score (partner→WAPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DNA2 →	+0.877	+0.257	<.001	<.001	3	8
HNSC	NOLC1 →	+0.614	+0.183	<.001	<.001	3	7
LSCC	KIF20B →	+0.969	+0.244	<.001	<.001	3	7
HNSC	PDCD11 →	+0.511	+0.118	.001	<.001	3	7
HNSC	EXOSC1 →	+0.472	+0.185	<.001	<.001	3	7
BRCA	KIF11 →	+0.826	+0.184	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,550 associations by consensus.

WAPL vs DNA2 — LSCC

Explore this scatter interactively →