WAPL

Across TCGA pan-cancer cohorts, WAPL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of WAPL’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WAPL RNA is repressed in tumor relative to normal tissue. In most cancer types WAPL is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where WAPL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WAPL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.586	<.001	9	view →
HNSC	All	All	+0.387	<.001	9	view →
LIHC	All	II,III,IV	+0.615	<.001	7	view →
KICH	Female	All	−0.947	<.001	5	view →
STAD	All	II,III,IV	+0.742	<.001	5	view →
COAD	Male	All	+0.366	.004	4	view →
BRCA	All	II,III,IV	+0.289	<.001	4	view →
CHOL	Male	All	+1.651	<.001	3	view →
PAAD	Female	All	−0.509	.003	2	view →
BLCA	Male	III,IV	+0.474	.006	2	view →
LUAD	Female	II,III,IV	−0.451	.014	2	view →
ESCA	Female	All	+0.913	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

WAPL–THCA

Open the THCA breakdown →