WAC

Across TCGA cell cohorts, WAC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,744 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WAC-associated GO terms across cancer lineages are Negative regulation of microtubule depolymerization, Mitochondrial RNA 3'-end processing, and Negative regulation of beige fat cell differentiation. Each is linked with WAC in more than 13 cancer types. Because this analysis shows association rather than direction, both WAC-to-partner and partner-to-WAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of microtubule depolymerization grouped by WAC-low versus WAC-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WAC→partner) and Y-score (partner→WAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of microtubule depolymerization →	+0.096	+1.003	<.001	<.001	3	14
OESOPHAGUS	Mitochondrial RNA 3'-end processing →	+0.143	+0.888	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of beige fat cell differentiation →	+0.134	+0.998	.001	.004	3	12
SOFT_TISSUE	Regulation of microtubule depolymerization →	+0.075	+0.644	.001	.004	3	12
LARGE_INTESTINE	Negative regulation of hippo signaling →	+0.108	+0.875	<.001	<.001	3	12
SOFT_TISSUE	RNA destabilization →	+0.069	+0.767	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,744 associations by consensus.

Negative regulation of microtubule depolymerization by WAC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →