WAC

Across TCGA pan-cancer cohorts, WAC RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated WAC data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher WAC RNA is associated with better overall survival. In most high-consensus cancer types, elevated WAC expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, ACC, and KIRP are the cancer types where WAC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.735	0.535	<.001	113	view →
ACC	DFS	Median	All	0.224	0.672	<.001	74	view →
KIRP	DFS	Tertile	All	0.861	0.959	.001	51	view →
LIHC	DFS	Tertile	All	0.427	0.630	<.001	49	view →
LGG	DFS	Median	All	0.801	0.660	<.001	42	view →
CESC	DFS	Tertile	III,IV	0.211	0.779	<.001	36	view →
SKCM	OS	Tertile	II,III,IV	0.897	0.776	.006	27	view →
THYM	DFS	Tertile	III,IV	1.000	0.236	.005	23	view →
GBM	DFS	Median	All	0.396	0.192	.002	21	view →
STAD	DFS	Median	II,III,IV	0.303	0.469	.006	20	view →
KICH	DFS	Quartile	II,III,IV	0.321	0.907	.010	19	view →
BLCA	DFS	Quartile	All	0.171	0.607	.002	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

WAC–KIRC (OS)

Open the KIRC breakdown →