WAC

Across TCGA pan-cancer cohorts, WAC RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of WAC’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where WAC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WAC is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, THCA, and HNSC are the cancer types where WAC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WAC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.878	<.001	9	view →
THCA	Male	II,III,IV	−0.686	<.001	9	view →
HNSC	All	All	+0.321	.003	6	view →
KICH	Female	All	−1.252	<.001	5	view →
CHOL	Male	All	+1.824	<.001	3	view →
ESCA	All	All	+0.398	.008	2	view →
KIRC	All	All	+0.233	.005	2	view →
STAD	Male	II,III,IV	+0.509	.045	1	view →
LUAD	Male	II,III,IV	+0.370	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

WAC–LIHC

Open the LIHC breakdown →