WAC

Across TCGA cell cohorts, WAC protein abundance is significantly associated with the go_rna of many other GO terms, with 1,854 significant associations in total. BONE shows the largest number of these associations.

The most reproducible WAC-associated GO terms across cancer lineages are Androgen metabolic process, Cellular response to ketone, and Amelogenesis. Each is linked with WAC in more than 2 cancer types. Because this analysis shows association rather than direction, both WAC-to-partner and partner-to-WAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Androgen metabolic process grouped by WAC-low versus WAC-high in LUNG_NSCLC_LUAD.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WAC→partner) and Y-score (partner→WAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Androgen metabolic process →	-0.150	-1.083	.003	.001	3	3
KIDNEY	Cellular response to ketone →	-0.077	-0.909	.003	.007	3	3
CNS	Amelogenesis →	+0.280	+1.167	<.001	<.001	3	3
SOFT_TISSUE	Regulation of hypersensitivity →	+0.292	+1.279	.002	.002	3	3
SOFT_TISSUE	Positive regulation of hypersensitivity →	+0.274	+1.279	.002	.002	3	3
SKIN	Pigment accumulation →	+0.149	+0.831	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,854 associations by consensus.

Androgen metabolic process by WAC expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →