WAC

Across TCGA cell cohorts, WAC mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WAC-associated genes across cancer lineages are SERPINA7, C1orf158, and GAGE12E. Each is linked with WAC in more than 1 cancer types. Because this analysis shows association rather than direction, both WAC-to-partner and partner-to-WAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA7 grouped by WAC-low versus WAC-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WAC→partner) and Y-score (partner→WAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	DPPA2 →	+0.177	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	FGF4 →	+0.018	+4.662	<.001	.003	3	1
LARGE_INTESTINE	VCY1B →	+0.656	+3.199	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SERPINA7 by WAC expression — BLOOD_Myeloma

Explore this box plot interactively →