VWDE

Across TCGA cell cohorts, VWDE mutation is significantly associated with the RNA expression of many other genes, with 582 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VWDE-associated genes across cancer lineages are OR3A1, KRTAP2-1, and NCAM2. Each is linked with VWDE in more than 1 cancer types. Because this analysis shows association rather than direction, both VWDE-to-partner and partner-to-VWDE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR3A1 grouped by VWDE-low versus VWDE-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWDE→partner) and Y-score (partner→VWDE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR3A1 →	+0.392	+2.752	<.001	.002	3	2
BLOOD_Leukemia	KRTAP2-1 →	+0.025	+3.232	<.001	.001	3	2
LUNG_NSCLC_LUAD	NCAM2 →	+0.737	+3.206	<.001	.008	3	2
LUNG_NSCLC_LUAD	MRPL20 →	+0.492	+3.431	.008	.002	3	2
LUNG_NSCLC_LUAD	SNRNP40 →	+0.526	+3.358	.007	.003	3	2
BLOOD_Lymphoma	CATSPERD →	+0.087	+3.823	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 582 associations by consensus.

OR3A1 by VWDE expression — BLOOD_Leukemia

Explore this box plot interactively →