VWDE

Across TCGA pan-cancer cohorts, VWDE RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated VWDE data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher VWDE RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VWDE expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.

UCEC, KIRP, and LGG are the cancer types where VWDE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.589	0.857	<.001	108	view →
KIRP	DFS	Tertile	II,III,IV	0.151	0.654	<.001	87	view →
LGG	OS	Median	All	0.351	0.519	<.001	54	view →
COAD	OS	Tertile	All	0.390	0.658	.002	36	view →
ESCA	OS	Tertile	All	0.633	0.346	.009	27	view →
STAD	DFS	Median	All	0.424	0.617	.003	26	view →
UVM	DFS	Tertile	All	0.268	0.633	.004	24	view →
OV	DFS	Median	IV	0.298	0.622	<.001	24	view →
SKCM	OS	Median	IV	1.000	0.267	.003	24	view →
CESC	DFS	Tertile	All	0.240	0.609	.004	20	view →
DLBC	DFS	Median	III,IV	0.074	0.984	.003	20	view →
THCA	DFS	Median	All	0.767	0.896	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

VWDE–UCEC (DFS)

Open the UCEC breakdown →