VWCE

Across TCGA cell cohorts, VWCE mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VWCE-associated genes across cancer lineages are KRTAP5-6, TLE7, and RPS12. Each is linked with VWCE in more than 1 cancer types. Because this analysis shows association rather than direction, both VWCE-to-partner and partner-to-VWCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-6 grouped by VWCE-low versus VWCE-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWCE→partner) and Y-score (partner→VWCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP5-6 →	+0.219	+3.289	<.001	.009	3	2
BLOOD_Leukemia	TLE7 →	+0.021	+3.969	<.001	.009	3	2
LARGE_INTESTINE	RPS12 →	+0.470	+3.169	.007	.009	3	1
LARGE_INTESTINE	C2orf42 →	+0.553	+3.237	<.001	.003	3	1
LARGE_INTESTINE	STXBP3 →	+0.427	+3.067	.006	.009	3	1
LARGE_INTESTINE	WARS2 →	+0.576	+3.252	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

KRTAP5-6 by VWCE expression — BLOOD_Leukemia

Explore this box plot interactively →