VWCE

Across TCGA pan-cancer cohorts, VWCE RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of VWCE’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VWCE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VWCE is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where VWCE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VWCE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+2.265	<.001	11	view →
KICH	Male	II,III,IV	−0.876	<.001	9	view →
HNSC	All	II,III,IV	−0.401	.002	8	view →
BRCA	All	II,III,IV	−0.989	<.001	6	view →
COAD	All	II,III,IV	+0.347	.005	5	view →
CHOL	Male	All	−2.251	<.001	2	view →
PRAD	All	All	−0.802	<.001	2	view →
PAAD	Male	All	−0.790	.026	2	view →
BLCA	All	IV	−0.667	.042	1	view →
STAD	All	II,III,IV	+0.404	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

VWCE–KIRC

Open the KIRC breakdown →