VWC2L

Across TCGA cell cohorts, VWC2L mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible VWC2L-associated genes across cancer lineages are KRTAP16-1, SLC22A8, and CLRN1. Each is linked with VWC2L in more than 1 cancer types. Because this analysis shows association rather than direction, both VWC2L-to-partner and partner-to-VWC2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP16-1 grouped by VWC2L-low versus VWC2L-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWC2L→partner) and Y-score (partner→VWC2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP16-1 →	+0.018	+3.297	<.001	.002	3	1
LUNG_NSCLC_LUAD	SLC22A8 →	+0.025	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	CLRN1 →	+0.025	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KRTAP16-1 by VWC2L expression — SKIN

Explore this box plot interactively →