VWA8

Across TCGA cell cohorts, VWA8 mutation is significantly associated with the RNA expression of many other genes, with 128 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VWA8-associated genes across cancer lineages are KHDC3L, PF4V1, and FAM71A. Each is linked with VWA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both VWA8-to-partner and partner-to-VWA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by VWA8-low versus VWA8-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA8→partner) and Y-score (partner→VWA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KHDC3L →	+0.055	+2.974	<.001	.006	3	3
LARGE_INTESTINE	PF4V1 →	+0.185	+2.378	<.001	.006	3	2
LARGE_INTESTINE	FAM71A →	+0.048	+2.353	.001	.008	3	2
BLOOD_Leukemia	GZMK →	+0.587	+3.359	<.001	.002	3	2
BLOOD_Leukemia	TSSK1B →	+0.012	+3.704	<.001	.001	3	2
CNS	MTRNR2L10 →	+0.008	+4.357	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 128 associations by consensus.

KHDC3L by VWA8 expression — OVARY

Explore this box plot interactively →