VWA3B

Across TCGA cell cohorts, VWA3B mutation is significantly associated with the RNA expression of many other genes, with 488 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VWA3B-associated genes across cancer lineages are ULBP1, HASPIN, and LEPROT. Each is linked with VWA3B in more than 1 cancer types. Because this analysis shows association rather than direction, both VWA3B-to-partner and partner-to-VWA3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ULBP1 grouped by VWA3B-low versus VWA3B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA3B→partner) and Y-score (partner→VWA3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ULBP1 →	+1.569	+3.199	<.001	.007	3	2
LARGE_INTESTINE	HASPIN →	+0.627	+2.043	.002	.008	3	2
LARGE_INTESTINE	LEPROT →	-0.369	-3.321	.004	.002	3	2
BLOOD_Leukemia	HSD17B6 →	+1.278	+3.199	<.001	.007	3	2
LARGE_INTESTINE	CCDC163 →	+0.506	+2.743	.002	.001	3	2
BLOOD_Leukemia	FAM149A →	+1.535	+3.502	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 488 associations by consensus.

ULBP1 by VWA3B expression — BLOOD_Leukemia

Explore this box plot interactively →