VWA3A

Across TCGA cell cohorts, VWA3A mutation is significantly associated with the RNA expression of many other genes, with 436 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VWA3A-associated genes across cancer lineages are KHDC3L, ASB10, and KRTAP10-10. Each is linked with VWA3A in more than 1 cancer types. Because this analysis shows association rather than direction, both VWA3A-to-partner and partner-to-VWA3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by VWA3A-low versus VWA3A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA3A→partner) and Y-score (partner→VWA3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KHDC3L →	+0.219	+3.774	<.001	.008	3	2
SOFT_TISSUE	ASB10 →	+0.015	+4.417	<.001	.004	3	1
SOFT_TISSUE	KRTAP10-10 →	+0.017	+4.977	<.001	.002	3	1
SOFT_TISSUE	GSTT4 →	+0.032	+4.977	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.574	+3.137	.005	.007	3	1
LARGE_INTESTINE	MCAT →	+0.757	+3.082	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 436 associations by consensus.

KHDC3L by VWA3A expression — BLOOD_Leukemia

Explore this box plot interactively →