VWA3A

Across TCGA pan-cancer cohorts, VWA3A RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated VWA3A data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher VWA3A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VWA3A expression acts as an unfavorable survival marker, although some lineages such as ESCA and BLCA show a favorable association.

KIRC, ESCA, and BLCA are the cancer types where VWA3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.528	0.711	<.001	114	view →
ESCA	OS	Median	III,IV	0.724	0.395	<.001	41	view →
BLCA	OS	Median	II,III,IV	0.771	0.649	.001	37	view →
COAD	DFS	Median	All	0.598	0.763	.001	37	view →
CESC	OS	Median	IV	0.680	0.096	.001	36	view →
UCEC	OS	Quartile	All	0.978	0.889	<.001	36	view →
BRCA	DFS	Quartile	III,IV	0.852	0.696	.017	25	view →
LUAD	OS	Median	IV	0.286	0.711	.019	18	view →
SCLC	OS	Tertile	II,III,IV	0.437	0.746	.014	17	view →
PRAD	DFS	Tertile	All	0.843	0.940	.002	16	view →
SKCM	DFS	Median	All	0.669	0.548	.007	15	view →
READ	OS	Quartile	III,IV	0.919	0.636	.021	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

VWA3A–KIRC (DFS)

Open the KIRC breakdown →