VSX1

Across TCGA cell cohorts, VSX1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VSX1-associated genes across cancer lineages are CLEC18C, OR4F4, and OR6Q1. Each is linked with VSX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSX1-to-partner and partner-to-VSX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC18C grouped by VSX1-low versus VSX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSX1→partner) and Y-score (partner→VSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLEC18C →	+0.182	+3.333	<.001	.009	3	1
LARGE_INTESTINE	OR4F4 →	+0.018	+3.103	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	FAM170A →	+0.161	+3.962	<.001	.002	3	1
LUNG_NSCLC_LUAD	KHDC3L →	+0.022	+3.215	.004	.007	3	1
LUNG_NSCLC_LUAD	LCN6 →	+0.041	+3.215	.008	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CLEC18C by VSX1 expression — LARGE_INTESTINE

Explore this box plot interactively →