VSX1

Across TCGA pan-cancer cohorts, VSX1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated VSX1 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher VSX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VSX1 expression acts as an unfavorable survival marker, although some lineages such as ACC and UVM show a favorable association.

KIRC, READ, and MESO are the cancer types where VSX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.534	0.715	<.001	72	view →
READ	DFS	Median	III,IV	0.508	0.893	<.001	54	view →
MESO	OS	Tertile	All	0.237	0.709	.006	44	view →
THCA	OS	Tertile	All	0.974	1.000	.001	39	view →
OV	OS	Tertile	II,III,IV	0.777	0.888	.003	38	view →
DLBC	OS	Quartile	II,III,IV	0.304	1.000	.010	32	view →
ACC	OS	Tertile	III,IV	0.841	0.306	.006	29	view →
LGG	OS	Median	All	0.851	0.937	<.001	26	view →
UVM	DFS	Median	II,III,IV	0.753	0.531	.034	21	view →
THYM	OS	Median	All	1.000	0.718	.001	20	view →
SARC	DFS	Tertile	All	0.628	0.458	.005	19	view →
TGCT	DFS	Median	All	0.753	0.904	.010	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

VSX1–KIRC (OS)

Open the KIRC breakdown →