VPS53

Across TCGA patient cohorts, VPS53 protein abundance is significantly associated with the RNA expression of many other genes, with 8,671 significant associations in total. GBM shows the largest number of these associations.

The most reproducible VPS53-associated genes across cancer lineages are ASL, PMPCB, and ZNHIT1. Each is linked with VPS53 in more than 4 cancer types. Because this analysis shows association rather than direction, both VPS53-to-partner and partner-to-VPS53 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VPS53 versus ASL in UCEC, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS53→partner) and Y-score (partner→VPS53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASL →	+0.531	+0.130	.001	.001	3	5
OV	PMPCB →	+0.464	+0.264	<.001	.002	3	4
UCEC	ZNHIT1 →	+0.536	+0.119	.002	<.001	3	4
UCEC	EXOC4 →	+0.459	+0.137	<.001	.001	3	4
UCEC	MKRN1 →	+0.620	+0.183	<.001	<.001	3	4
OV	CDK5 →	+0.522	+0.320	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,671 associations by consensus.

VPS53 vs ASL — UCEC

Explore this scatter interactively →