VPS53

Across TCGA pan-cancer cohorts, VPS53 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of VPS53’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where VPS53 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS53 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

LIHC, KIRC, and CHOL are the cancer types where VPS53 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS53 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.843	<.001	8	view →
KIRC	Male	II,III,IV	−0.393	<.001	6	view →
CHOL	Male	All	+1.731	<.001	5	view →
BRCA	Female	All	−0.146	.016	5	view →
KICH	All	All	−0.453	<.001	4	view →
STAD	All	All	+0.398	.021	4	view →
HNSC	All	All	+0.290	.003	4	view →
COAD	All	II,III,IV	+0.240	.015	4	view →
UCEC	All	III,IV	+0.674	.033	2	view →
KIRP	Female	II,III,IV	+0.632	.044	2	view →
PRAD	All	All	+0.254	.001	2	view →
THCA	All	All	−0.201	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

VPS53–LIHC

Open the LIHC breakdown →