VPS41

Across TCGA cell cohorts, VPS41 mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS41-associated genes across cancer lineages are OR4E1, IL22, and HS3ST2. Each is linked with VPS41 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS41-to-partner and partner-to-VPS41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4E1 grouped by VPS41-low versus VPS41-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS41→partner) and Y-score (partner→VPS41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR4E1 →	+0.006	+4.450	<.001	.004	3	1
LUNG_NSCLC_LUAD	IL22 →	+0.038	+4.212	.003	.007	3	1
STOMACH	HS3ST2 →	+0.053	+4.050	<.001	.002	3	1
LARGE_INTESTINE	GBE1 →	+0.642	+3.364	.008	.002	3	1
LARGE_INTESTINE	NQO2 →	+0.926	+3.364	.005	.002	3	1
LARGE_INTESTINE	PRH2 →	+0.086	+3.537	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

OR4E1 by VPS41 expression — OVARY

Explore this box plot interactively →