VPS41

Across TCGA pan-cancer cohorts, VPS41 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of VPS41’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VPS41 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS41 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, LIHC, and KIRP are the cancer types where VPS41 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS41 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.663	<.001	11	view →
LIHC	Female	II,III,IV	+1.185	<.001	8	view →
KIRP	Female	II,III,IV	+0.776	.014	6	view →
CHOL	Female	All	+2.583	<.001	5	view →
COAD	Male	All	+0.383	<.001	5	view →
STAD	Male	II,III,IV	+0.660	.011	3	view →
BRCA	All	II,III,IV	+0.204	.005	3	view →
KICH	All	All	−0.480	.007	2	view →
UCEC	All	All	−0.467	.011	2	view →
LUAD	All	All	+0.159	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

VPS41–HNSC

Open the HNSC breakdown →