VPS37D

Across TCGA patient cohorts, VPS37D mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS37D-associated genes across cancer lineages are RNU6-203P, RNU6-1313P, and RNU6-533P. Each is linked with VPS37D in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS37D-to-partner and partner-to-VPS37D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-203P grouped by VPS37D-low versus VPS37D-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS37D→partner) and Y-score (partner→VPS37D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-203P →	+0.384	+7.741	<.001	.009	3	2
COAD	RNU6-1313P →	+0.593	+7.741	<.001	.009	3	1
COAD	RNU6-533P →	+0.571	+7.741	<.001	.009	3	1
SKCM	PRAMEF34P →	+0.019	+7.816	<.001	.008	3	1
SKCM	SMIM34B →	+0.029	+7.816	<.001	.008	3	1
UCEC	RNU1-93P →	+0.495	+5.771	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

RNU6-203P by VPS37D expression — COAD

Explore this box plot interactively →