VPS37D

Across TCGA pan-cancer cohorts, VPS37D RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of VPS37D’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where VPS37D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS37D is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

LUAD, KICH, and COAD are the cancer types where VPS37D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS37D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	IV	+2.135	<.001	11	view →
KICH	Female	II,III,IV	−2.132	<.001	11	view →
COAD	All	II,III,IV	+0.717	<.001	10	view →
LIHC	Male	All	+1.037	<.001	7	view →
KIRC	All	II,III,IV	−0.571	<.001	7	view →
THCA	Male	All	−0.494	<.001	7	view →
BRCA	All	II,III,IV	+0.427	<.001	6	view →
LUSC	All	All	+1.181	<.001	5	view →
READ	All	III,IV	−0.509	.015	2	view →
PRAD	All	All	−0.503	<.001	2	view →
STAD	Female	III,IV	−1.110	.045	1	view →
ESCA	Male	All	+0.790	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

VPS37D–LUAD

Open the LUAD breakdown →