VPS33A

Across TCGA patient cohorts, VPS33A mutation is significantly associated with the RNA expression of many other genes, with 4,247 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS33A-associated genes across cancer lineages are SKA3, PBK, and RNA5SP419. Each is linked with VPS33A in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS33A-to-partner and partner-to-VPS33A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA3 grouped by VPS33A-low versus VPS33A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS33A→partner) and Y-score (partner→VPS33A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA3 →	+0.810	+2.665	<.001	<.001	3	3
UCEC	PBK →	+1.016	+2.654	<.001	<.001	3	3
UCEC	RNA5SP419 →	+0.390	+1.924	.002	.001	3	3
LIHC	RNU6-311P →	+0.274	+5.676	<.001	.001	3	3
UCEC	DDX55 →	+0.484	+2.513	<.001	<.001	3	3
UCEC	ENOPH1 →	+0.640	+4.269	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,247 associations by consensus.

SKA3 by VPS33A expression — UCEC

Explore this box plot interactively →