VPS33A

Across TCGA pan-cancer cohorts, VPS33A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated VPS33A data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher VPS33A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS33A expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

KICH, LIHC, and UCS are the cancer types where VPS33A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.240	1.000	.001	99	view →
LIHC	OS	Median	All	0.604	0.766	<.001	95	view →
UCS	OS	Tertile	III,IV	0.722	0.228	.001	60	view →
BLCA	OS	Quartile	All	0.371	0.758	<.001	56	view →
KIRC	DFS	Quartile	II,III,IV	0.864	0.476	<.001	38	view →
UCEC	DFS	Tertile	All	0.787	0.891	.002	24	view →
HNSC	DFS	Median	All	0.230	0.460	.002	23	view →
BRCA	DFS	Quartile	III,IV	0.857	0.698	.012	23	view →
LUSC	DFS	Tertile	III,IV	0.207	0.731	.008	19	view →
UVM	DFS	Quartile	II,III,IV	0.275	0.762	.005	16	view →
PAAD	DFS	Quartile	All	0.592	0.323	.007	15	view →
THYM	OS	Tertile	All	1.000	0.877	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

VPS33A–KICH (DFS)

Open the KICH breakdown →