Across TCGA patient cohorts, VPS13A protein abundance is significantly associated with the RNA expression of many other genes, with 7,504 significant associations in total. GBM shows the largest number of these associations.

The most reproducible VPS13A-associated genes across cancer lineages are ALAD, CDK20, and NOXA1. Each is linked with VPS13A in more than 5 cancer types. Because this analysis shows association rather than direction, both VPS13A-to-partner and partner-to-VPS13A results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13A→partner) and Y-score (partner→VPS13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ALAD →	+0.439	+0.231	<.001	<.001	3	6
LSCC	CDK20 →	+0.645	+0.273	<.001	<.001	3	5
HNSC	NOXA1 →	+0.840	+0.137	.006	.004	3	5
GBM	RALGPS1 →	+0.793	+0.303	<.001	<.001	3	5
OV	RFK →	+0.779	+0.311	<.001	<.001	3	4
OV	IDNK →	+0.617	+0.199	.001	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,504 associations by consensus.

Exploration

VPS13A survival (RNA) · tumor vs normal (RNA) · all VPS13A data types