Across TCGA pan-cancer cohorts, VPS13A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated VPS13A data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher VPS13A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS13A expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRC, ACC, and LIHC are the cancer types where VPS13A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.714	0.543	<.001	97	view →
ACC	DFS	Median	All	0.388	0.760	<.001	61	view →
LIHC	DFS	Median	All	0.481	0.602	.002	48	view →
READ	OS	Median	II,III,IV	0.869	0.397	.002	33	view →
MESO	DFS	Median	II,III,IV	0.234	0.667	.001	30	view →
SKCM	DFS	Quartile	All	0.245	0.133	.004	23	view →
SCLC	DFS	Quartile	II,III,IV	0.679	0.204	.006	21	view →
KIRP	DFS	Median	All	0.978	0.796	.007	21	view →
UVM	DFS	Quartile	III,IV	0.232	0.832	.004	18	view →
UCS	OS	Median	All	0.593	0.758	.022	18	view →
THYM	DFS	Median	All	0.961	0.847	.006	18	view →
LGG	OS	Median	All	0.762	0.893	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: VPS13A tumor-vs-normal RNA expression · all VPS13A data types