Across TCGA patient cohorts, VPS13A mutation is significantly associated with the RNA expression of many other genes, with 8,117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS13A-associated genes across cancer lineages are ENO2, CDCA2, and ENDOG. Each is linked with VPS13A in more than 4 cancer types. Because this analysis shows association rather than direction, both VPS13A-to-partner and partner-to-VPS13A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13A→partner) and Y-score (partner→VPS13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENO2 →	+0.548	+1.458	<.001	.001	3	5
UCEC	CDCA2 →	+0.815	+2.025	<.001	<.001	3	5
UCEC	ENDOG →	+0.356	+1.277	.003	.002	3	5
UCEC	B3GNT4 →	+0.346	+1.463	<.001	<.001	3	5
UCEC	PHF5A →	+0.467	+2.297	<.001	<.001	3	4
UCEC	PLEKHJ1 →	+0.603	+2.168	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,117 associations by consensus.

Exploration

VPS13A survival (RNA) · tumor vs normal (RNA) · all VPS13A data types