Across TCGA patient cohorts, VPS13A mutation is significantly associated with the total protein of many other genes, with 89 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS13A-associated genes across cancer lineages are 4E-BP1, ATM, and Caspase-7-cleavedD198. Each is linked with VPS13A in more than 3 cancer types. Because this analysis shows association rather than direction, both VPS13A-to-partner and partner-to-VPS13A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13A→partner) and Y-score (partner→VPS13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.259	+1.436	<.001	<.001	3	4
UCEC	ATM →	-0.535	-1.678	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+0.778	+2.321	.009	.033	3	4
BRCA	Rab25 →	-0.331	-2.700	.014	.006	3	3
STAD	FASN →	+0.447	+3.185	.004	.009	3	3
STAD	PREX1 →	+0.204	+2.321	.023	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

Exploration

VPS13A survival (RNA) · tumor vs normal (RNA) · all VPS13A data types