Across TCGA cell cohorts, VPS13A mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS13A-associated genes across cancer lineages are PRR14L, EML5, and BCDIN3D. Each is linked with VPS13A in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS13A-to-partner and partner-to-VPS13A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13A→partner) and Y-score (partner→VPS13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRR14L →	+0.604	+3.276	<.001	.004	3	3
BLOOD_Leukemia	EML5 →	+0.859	+3.411	<.001	.003	3	3
BLOOD_Leukemia	BCDIN3D →	+0.460	+3.351	.004	.003	3	3
URINARY_TRACT	FGF8 →	+0.177	+3.373	.002	.004	3	2
PANCREAS	UBE2U →	+0.140	+2.748	.002	.002	3	2
CNS	TBATA →	+0.010	+4.035	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

Exploration

VPS13A survival (RNA) · tumor vs normal (RNA) · all VPS13A data types