VNN3

Across TCGA cell cohorts, VNN3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VNN3-associated genes across cancer lineages are BPIFB6, HTR1E, and UTF1. Each is linked with VNN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both VNN3-to-partner and partner-to-VNN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by VNN3-low versus VNN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VNN3→partner) and Y-score (partner→VNN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	HTR1E →	+0.085	+3.930	<.001	.003	3	1
LARGE_INTESTINE	UTF1 →	+0.022	+4.217	<.001	.001	3	1
LARGE_INTESTINE	RIPPLY2 →	+0.596	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR2J3 →	+0.040	+3.920	<.001	.005	3	1
LARGE_INTESTINE	TMEM233 →	+0.353	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

BPIFB6 by VNN3 expression — LARGE_INTESTINE

Explore this box plot interactively →