VNN3

Across TCGA pan-cancer cohorts, VNN3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated VNN3 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher VNN3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VNN3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

STAD, KIRC, and THCA are the cancer types where VNN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.467	0.645	<.001	106	view →
KIRC	DFS	Quartile	All	0.498	0.691	<.001	74	view →
THCA	DFS	Median	II,III,IV	0.554	0.860	<.001	67	view →
HNSC	OS	Quartile	IV	0.800	0.583	.003	39	view →
LGG	OS	Quartile	All	0.726	0.875	.001	28	view →
GBM	DFS	Tertile	All	0.187	0.322	.003	27	view →
OV	DFS	Quartile	IV	0.270	0.575	.001	24	view →
LAML	DFS	Tertile	All	0.424	0.770	.004	24	view →
READ	OS	Median	All	0.957	0.546	.022	14	view →
COAD	OS	Median	All	0.954	0.782	<.001	13	view →
ESCA	DFS	Quartile	III,IV	0.467	0.211	.006	12	view →
UCS	DFS	Tertile	IV	0.860	0.323	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

VNN3–STAD (DFS)

Open the STAD breakdown →