VNN1

Across TCGA patient cohorts, VNN1 mutation is significantly associated with the RNA expression of many other genes, with 1,922 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VNN1-associated genes across cancer lineages are DHRS11, RPL23AP82, and PSMC1P1. Each is linked with VNN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both VNN1-to-partner and partner-to-VNN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHRS11 grouped by VNN1-low versus VNN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VNN1→partner) and Y-score (partner→VNN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHRS11 →	+0.471	+2.601	<.001	<.001	3	3
UCEC	RPL23AP82 →	+0.446	+4.191	<.001	<.001	3	3
UCEC	PSMC1P1 →	+0.355	+2.243	.003	.005	3	3
LUSC	LINC01639 →	+0.924	+3.714	<.001	.004	3	3
UCEC	LACTB →	+0.436	+2.839	<.001	.001	3	3
UCEC	HSPA9 →	+0.439	+2.839	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,922 associations by consensus.

DHRS11 by VNN1 expression — UCEC

Explore this box plot interactively →