VNN1

Across TCGA pan-cancer cohorts, VNN1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated VNN1 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher VNN1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated VNN1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and HNSC show a favorable association.

DLBC, OV, and HNSC are the cancer types where VNN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	All	0.924	0.310	.001	72	view →
OV	OS	Median	IV	0.610	0.870	.001	64	view →
HNSC	OS	Tertile	III,IV	0.817	0.637	.001	53	view →
SKCM	OS	Tertile	All	0.423	0.267	.001	49	view →
LGG	OS	Tertile	All	0.838	0.942	<.001	40	view →
UCEC	DFS	Median	II,III,IV	0.712	0.385	.004	38	view →
LAML	DFS	Median	All	0.260	0.491	.001	38	view →
ESCA	OS	Median	All	0.449	1.000	.011	23	view →
STAD	DFS	Median	III,IV	0.472	0.736	.004	16	view →
LUAD	OS	Tertile	II,III,IV	0.344	0.564	.017	13	view →
THCA	DFS	Median	IV	0.871	0.436	.001	10	view →
LUSC	DFS	Median	All	0.719	0.795	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

VNN1–DLBC (DFS)

Open the DLBC breakdown →